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Most reports were in patients taking the alpha adrenergic antagonist when IFIS occurred, but in some cases, the alpha adrenergic antagonist had been stopped prior to surgery.
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One short-term trial reported greater patient satisfaction and less bothersome incontinence symptoms with behavioral therapy compared with the use of pessaries at 3 months, but these differences were not sustained at 12 months; further, combination therapy was not superior to behavioral therapy alone or the use of pessaries alone.
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These people live healthy lives without any increased disease risk (In matter of fact, they do not experience male pattern hair loss, their prostates do not enlarge, and they do not develop prostate cancer).
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Food and Drug Administration (FDA) is informing healthcare professionals that the Warnings and Precautions section of the labels for the 5-alpha reductase inhibitor (5-ARI) class of drugs has been revised to include new safety information about the increased risk of being diagnosed with a more serious form of prostate cancer (high-grade prostate cancer).
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In an embryo-fetal development study, pregnant rhesus monkeys were exposed intravenously to a dutasteride blood level comparable to the dutasteride concentration found in human semen.
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